Current Project : Brain Reconstruction

Brain Reconstruction

About Brain Reconstruction

The objective of this project is to visualize interactively in 3D the presence the b-amyloid peptide (Ab) within the brain of a rat. The Ab peptide molecule is believed by most researchers to play a major role in the etiopathogenesis of Alzheimer's disease. We are doing this project in collaboration with Professor Nasser Zawie (PHA), who studies environmental effects such as exposure to lead or alcohol in the development of AD.

We analyze a stack of images of stained histological slices of a rat's brain. Different stainings reveal the outer contour of the brain, the main structures within the brain, and the presence of the Ab peptide. We determine the contour of the brain and use this information to register, that is, to "align" the different slices to reconstruct the brain, which can then be rendered using a volume rendering technique.